Publications

At Florida state university

 

2016


Schrell, A. M.; Mukhitov, N.; Yi, L.; Adablah, J. E.; Menezes, J.; Roper, M. G. "Online fluorescence anisotropy immunoassay for monitoring insulin secretion from islets of Langerhans" Analytical Methods 2016 DOI: 10.1039/C6AY02899CPDF


McKenna, J.P.; Dhumpa, R.; Mukhitov, N.; Roper, M. G.; Bertram, R. "Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets" PLoS Computational Biology 2016, 12, e1005143  PDF


Yi, L.; Bandak, B.; Wang, X.; Bertram, R.; Roper, M. G. "Dual detection system for simultaneous measurement of intracellular fluorescent markers and cellular secretion" Analytical Chemistry 2016, 88,10368-10373   PDF


Schrell, A. M.; Mukhitov, N.; Roper, M. G. "Multiplexing fluorescence anisotropy using frequency encoding" Analytical Chemistry 2016, 88, 7910-7915. PDF


Schrell, A. M.; Mukhitov, N.; Yi, L.; Wang, X.; Roper, M. G. "Microfluidic devices for the measurement of cellular secretion". Annual Reviews of Analytical Chemistry 2016, 9, 249-269.  PDF


Wang, X.; Yi, L.; Roper, M. G. “Microfluidic device for the measurement of amino acid secretion dynamics from murine and human islets of Langerhans” Analytical Chemistry 2016, 88, 3369-3375. PDF

Yi, L.; Wang, X.; Bethge, L.; Klussmann, S.; Roper, M. G. “Noncompetitive affinity assays of glucagon and amylin using mirror-image aptamers as affinity probes” Analyst 2016, 141, 1939-1946. PDF


Mukhitov, N.; Spear, J. M.; Stagg, S. M.; Roper, M. G. “Interfacing microfluidics with negative stain transmission electron microscopy” Analytical Chemistry 2016, 88, 629-634.  PDF


Roper, M. G. “Cellular analysis using microfluidics” Analytical Chemistry 2016, 88, 381-394.  PDF



2015

Dhumpa, R.; Truong, T. M.; Wang, X.; Roper, M. G. "Measurement of the entrainment window of islets of Langerhans by microfluidic delivery of a chirped glucose waveform" Integrative Biology 2015, 7:1061-1067.PDF


Wang, X.; Yi, L.; Guillo, C.; Roper, M. G. “Micellar electrokinetic chromatography method for measuring amino acid secretions from islets of Langerhans” Electrophoresis, 36:1172-1178.  PDF

Yi, L.; Wang, X.; Dhumpa, R.; Schrell, A. M.; Mukhitov, N.; Roper, M. G. “Integrated perfusion and separation systems for entrainment of insulin secretion from islets of Langerhans” Lab on a Chip 2015, 15, 823-832.  PDF

Wang, X.; Yi, L.; Mukhitov, N.; Schrell, A. M.; Dhumpa, R.; Roper, M. G. “Microfluidics-to-mass spectrometry: A review of coupling methods and applications” Journal of Chromatography A 2015, 1382C: 98-116.  PDF


2014

Mukhitov, N.; Yi, L.; Schrell, A. M.; Roper, M. G. “Optimization of a microfluidic electrophoretic immunoassay using a Peltier cooler” Journal of Chromatography A, 2014, 1367, 154-160.  PDF

Wang, X.; Roper, M. G. “Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans” Analytical Methods 2014, 6, 3019-3024.  PDF

Dhumpa, R.; Truong, T. M.; Wang, X.; Bertram, R.; Roper, M. G. “Negative feedback synchronizes islets of Langerhans” Biophysical Journal 2014, 106, 2275-2282.  PDF

Schrell, A. M.; Roper, M. G. “Frequency-encoded laser-induced fluorescence for multiplexed detection in infrared-mediated quantitative PCR” Analyst 2014, 139, 2695-2701.  PDF  *cover of Analyst, issue 11, 2014.  


2013

Lomasney, A. R.; Li, Y.; Roper, M. G. “Simultaneous monitoring of insulin and islet amyloid polypeptide secretion from islets of Langerhans on a microfluidic device” Analytical Chemistry 2013, 85, 7919-7925.  PDF

Zhang, X.; Dhumpa, R.; Roper, M. G. “Maintaining stimulant waveforms in large-volume microfluidic cell chambers” Microfluidics and Nanofluidics 2013, 15, 65-71.  PDF


2012

Dhumpa, R.; Roper, M. G. “Temporal gradients in microfluidic systems to probe cellular dynamics: A review” Analytica Chimica Acta 2012, 743, 9-18.  PDF

Baker, C. A.; Roper, M. G. “Online coupling of digital microfluidic devices with mass spectrometry detection using an eductor with electrospray ionization” Analytical Chemistry 2012, 84, 2955-2960.  PDF

Yu, Y.; Li, B.; Baker, C. A.; Zhang, X.; Roper, M. G. “Quantitative polymerase chain reaction using infrared heating on a microfluidic chip” Analytical Chemistry 2012, 84, 2825-2829.  PDF

Duong, C. T.; Roper, M. G. “A microfluidic device for the automated derivatization of free fatty acids to fatty acid methyl esters” Analyst 2012, 137, 840-846. PDF


2011

Zhang, X.; Daou, A.; Truong, T. M.; Bertram, R.; Roper, M. G. “Synchronization of mouse islets of Langerhans by glucose waveforms”  American Journal of Physiology - Endocrinology and Metabolism 2011, 301, E742-E747.  PDF

Guillo, C.; Truong, T. M.; Roper, M. G. “Simultaneous capillary electrophoresis competitive immunoassay for insulin, glucagon, and islet amyloid polypeptide secretion from mouse islets of Langerhans” Journal of Chromatography A 2011, 1218, 4059-4064. PDF

Baker, C. A.; Bulloch, R.; Roper, M. G. “Comparison of separation performance of laser-ablated and wet-etched microfluidic devices” Analytical and Bioanalytical Chemistry 2011, 399, 1473-1479.  PDF


2010

Zhang, X.; Grimley, A.; Bertram, R.; Roper, M. G. “Microfluidic system for generation of sinusoidal gluocse waveforms for entrainment of islets of Langerhans” Analytical Chemistry 2010, 82, 6704-6711. PDF

Cao, L.; Zhang, X.; Grimley, A.; Lomasney, A. R.; Roper, M. G. “Microfluidic multi-analyte gradient generator” Analytical and Bioanalytical Chemistry 2010, 398, 1985-1991. PDF

Baker, C. A.; Roper, M. G. “A continuous-flow, microchip electrophoresis fraction collector” Journal of Chromatography A 2010, 1217, 4743-4748. PDF 


2009

Baker, C. A.; Duong, C. T.; Grimley, A.; Roper, M. G. “Recent advances in microfluidic detection systems” Bioanalysis 2009, 1, 967-975. PDF

Lomasney, A. R.; Guillo, C.; Sidebottom, A. M.; Roper, M. G. “Optimization of capillary electrophoresis conditions for glucagon competitive immunoassay using response surface methodology” Analytical and Bioanalytical Chemistry 2009, 394, 313-319. PDF

Zhang, X.; Roper, M. G. “Microfluidic perfusion system for automated delivery of temporal gradients to biological cells” Analytical Chemistry 2009, 81, 1162-1168. PDF

Roper, M. G.; Guillo, C. “New technologies in affinity assays to explore cellular communication” Analytical and Bioanalytical Chemistry 2009, 393, 459-465. PDF


2008

Guillo, C.; Roper, M. G. “Affinity assays for detection of cellular communication and biomarkers” Analyst 2008, 133, 1481-1485. PDF

Tierno, P.; Reddy, S. V.; Roper, M. G.; Jofansen, T. H.; Fischer, T. M. “Transport and separation of biomolecular cargo on paramagnetic colloidal particles in a magnetic ratchet” Journal of Physical Chemistry B 2008, 112, 3833-3837. PDF

Guillo, C.; Roper, M. G. “Two-color electrophoretic immunoassay for simultaneous measurement of insulin and glucagon content in islets of Langerhans” Electrophoresis 2008, 29, 410-416. PDF


2007

Roper, M. G.; Easley, C. J.; Legendre, L. A.; Humphrey, J. A. C.; Landers, J. P. "Completely Non-Contact Temperature Control and Sensing on a Microfluidic Chip" Analytical Chemistry 2007, 79, 1294-1300.  PDF


2006

Easley, C. J.; Karlinsey, J. M.; Bienvenue, J. M.; Legendre, L. A.; Roper, M. G.; Feldman, S. H.; Hughes, M. A.; Hewlett, E. L.; Merkel, T. J.; Ferrance, J. P.; Landers, J. P. "A Fully-Integrated Microfludidic Genetic Analysis System with Sample in-Answer Out Capability" Proceedings of the National Academy of Sciences, USA 2006, 103, 19272-19277.  PDF

Roper, M. G.; Frisk, M. L.; Oberlander, J. P.; Ferrance, J. P.; McGrory, B. J.; Landers, J. P. "Extraction of C-Reactive Protein from Serum On a Microfluidic Chip" Analytica Chimica Acta 2006, 569, 195-202.  PDF

Yue, G. E.; Roper, M. G.; Balchunas, C.; Pulsipher, A.; Coon, J. J.; Shabanowitz, J.; Hunt, D. F.; Landers, J. P.; Ferrance, J. P. "Protein Digestion and Phosphopeptide Enrichment on a Glass Microchip" Analytica Chimica Acta 2006, 564, 116-122.  PDF

Legendre, L. A.; Bienvenue, J. M.; Roper, M. G.; Ferrance, J. P.; Landers, J. P. "A Simple, Valveless Microfluidic Sample Preparation Device for Extraction and Amplification of DNA from Nanolinter-Volume Samples" Analytical Chemistry 2006, 78, 1444-1451.  PDF


2005

Roper, M. G.; Easley, C. J.; Landers, J. P. "Advances in Polymerase Chain Reaction on Microfluidic Chips" Analytical Chemistry 2005, 77, 3887-3894.  PDF

Yue, G. E.; Roper, M. G.; Jeffery, E. D.; Easley, C. J.; Balchunas, C.; Landers, J. P.; Ferrance, J. P. "Glass Microfluidic Devices with Thin Membrane Voltage Junctions for Electrospray Mass Spectrometry" Lab on a Chip 2005, 5, 619-627.  PDF

Easley, C. J.; Legendre, L. A.; Roper, M. G.; Wavering, T. A.; Ferrance, J. P.; Landers, J. P. "Extrinsic Fabry-Perot Interferometry for Noncontact Temperature Control of Nanoliter-Volume Enzymatic Reactions in Glass Microchips" Analytical Chemistry 2005, 77, 1038-1045.  PDF


2004

Kulkarni, R. N.; Roper, M. G.; Dahlgren, G. M.; Kauri, L. M.; Kahn, C. R.; Kennedy, R. T. "Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2B and -3" Diabetes 2004, 53, 1517-1525.  PDF


2003

Roper, M. G.; Shackman, J. G.; Dahlgren, G. M.; Kennedy, R. T. "Microfluidic Chip for Continuous Monitoring of Hormone Secretion from Live Cells Using an Electrophoresis-Based Immunoassasy" Analytical Chemistry 2003, 75, 4711-4717.  PDF


2002

Roper, M. G.; Qian, W-J.; Zhang, B. B.; Kulkarni, R. N.; Kahn, C. R.; Kennedy, R. T. “Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca2+] and Insulin Secretion From Pancreatic β-Cells” Diabetes 2002, 51, S43-S49.  PDF


2001

German, I.; Roper, M. G.; Kalra, S. P.; Rhinehart, E.; Kennedy, R. T. "Capillary Liquid Chromatography of Multiple Peptides with On-Line Capillary Electrophoresis Immunoassay Detection" Electrophoresis 2001, 22, 3659-3667.  PDF


2000

Aspinwall, C. A.; Qian, W-J.; Roper, M. G.; Kulkarni, R. N.; Kahn, C. R.; Kennedy, R. T. "Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-Stimulated Insulin Secretion in β-Cells" Journal of Biological Chemistry 2000, 275, 22331-22338.  PDF